Many parents of adults with mental illness have confirmed that the initial symptoms of the patient's "not right" started in childhood. Canadian researchers recently isolated a DCC gene that is responsible for the dopamine connection in the medial prefrontal cortex of puberty. Studies conducted on mouse models have shown that the behavioral consequences of this gene's dysfunction during adolescence can continue into adulthood. At this teenage stage of brain development, adolescents are particularly vulnerable to mental illnesses such as schizophrenia, depression and drug addiction. The research results of Douglas College Research Center affiliated with McGill University provide the first clue for a comprehensive understanding of this important brain development stage. "Some mental disorders may be related to changes in the function of the prefrontal cortex, which changes the activity of the brain chemical dopamine." Said Ceresia Flores, a professor of psychiatry at McGill University, "the connection of the prefrontal cortex will be It continues to develop in early adulthood, but the mechanism is completely unknown until now. " The research results published in "Transformative Psychiatry" show that even a small change in DCC during adolescence will bring significant changes after the function of the prefrontal cortex. To determine whether the basic research results are applicable to human subjects, the researchers examined the expression of DCC in the brains of suicide victims. It is worth noting that these brains showed high levels of DCC expression, about 48% higher than the control group. Dr. Flores explained that the prefrontal cortex is associated with judgment, decision-making, and mental flexibility. It has the ability to change plans in the face of obstacles, and its normal operation is essential for learning, motivation, and cognitive processes. Given that it will continue to develop into adulthood, this area is particularly susceptible to adolescent life experiences (such as stress and drug abuse). Such changes in prefrontal cortical development can have long-term consequences for later life. By identifying the first molecule involved in the maturation of the prefrontal dopamine system, the researchers are now investigating further to develop drugs and other treatments. Flores believes that the DCC gene can be changed through life experience in adolescence, and the hope that this brings is that therapy including social support is itself a life experience, or can modify the DCC in this critical period of life Gene function, thereby reducing the susceptibility to mental illness. The consensus of psychiatry is that early treatment and counseling immediately after the onset of mental health problems are more significant for the healthy psychological development of adults.
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Adding genes that affect the function of prefrontal cortex