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Biosafety cabinet performance analysis
**Biosafety Cabinet Performance Analysis**
Some people may think that a biosafety cabinet is just an iron box with a fan and some HEPA filters. In reality, it's much more complex than that. Maintaining the safety of a biosafety cabinet is not as simple as "regular filter replacement." The purpose of this article is to address the performance and safety issues of biosafety cabinets and provide practical guidance for laboratory staff, managers, and other personnel involved in the operation and maintenance of these critical pieces of equipment.
**Filters**
The filter is one of the most important components in a biosafety cabinet. It plays a crucial role in purifying the air that enters and exits the cabinet by removing bacteria, dust, and other harmful particles. The filters used must have high efficiency to effectively protect against biological hazards. Typically, silica glass fiber is used as the filter material. Commonly used filters include HEPA (High-Efficiency Particulate Air) filters, which have a 99.99% efficiency for 0.3μm particles, and ULPA (Ultra-Low Penetration Air) filters, which offer even higher efficiency at 99.9998%. ULPA filters are more advanced, with tighter structures and larger filtration areas, providing ISO Class 3 cleanliness in the work zone.
**Fan System**
A properly designed fan system is essential for maintaining consistent airflow within the biosafety cabinet. It should include automatic air volume compensation to maintain stable airflow even when the filter pressure drops. The motor should also have thermal protection to ensure reliable operation under varying voltage conditions. Centrifugal outer rotor fans are widely used in cleanroom environments due to their compact design, lightweight construction, excellent balance, fast heat dissipation, and 100% speed control. These features contribute to long service life and stable performance.
**Interlock Alarm System**
Type B2 Class II biosafety cabinets require an interlock alarm system for both internal and external fans. This system ensures that the cabinet operates safely and alerts users to any potential failures or malfunctions.
**Airflow Control and the Concept of “Airflow Safety Performance Zoneâ€**
Airflow control is the core technology of biosafety cabinets. A qualified biosafety cabinet must not only meet the required airflow rate but also ensure directional, stable, and uniform airflow to meet biohazard testing standards. International standards such as NSF49 (U.S.) and EN12469 (EU) define minimum inlet airflow speeds—0.5 m/s and 0.40 m/s respectively. The airflow speed must be carefully balanced; too high can cause turbulence, while too low can compromise protection. Manufacturers should conduct airflow tests on all models to determine the optimal airflow safety zone and settings, ensuring maximum protection for users.
Shanghai Sujing Industrial Co., Ltd., located at No. 6, Lane 358, Wencheng Road, Songjiang New City, Shanghai, is a leading manufacturer in the purification equipment industry in East China. The company provides professional air purification system engineering design, construction, testing, and technical services tailored to national GMP requirements for industries such as microelectronics, biomedicine, hospital operating rooms, fiber optics, food and beverage, precision instruments, semiconductors, and new materials.
Sujing’s product lines, including purification workbenches, air showers, fume hoods, and biosafety cabinets, are widely used in medical, pharmaceutical, scientific research, agriculture, food, aerospace, automotive, and academic institutions. The company enjoys a strong reputation in domestic and Southeast Asian markets.
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