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First launched iPS cell therapy test
In addition, the study confirmed that when these induced pluripotent stem (iPS) cells were first guided to differentiate into more specialized cell types, they could be safely transplanted back into animals without causing an inflammatory reaction. These results bring hope for the future clinical use of iPS cells in human medicine.
The research team emphasized: "This study is highly important given the ongoing debates in this field. It offers strong evidence that these cells are not rejected by the immune system."
Pluripotent stem cells have the ability to develop into various specialized cell types, making them a promising option for treating conditions like Parkinson’s disease, certain types of diabetes, and vision loss. A major advantage of iPS cells, which are created by reprogramming adult cells, is that the resulting tissues are genetically matched to the recipient, reducing the risk of rejection.
Scientists are actively exploring iPS cell-based therapies, and a Japanese research group recently started enrolling patients for a human trial. However, previous studies in mice have raised concerns, showing that even genetically matched iPS-derived cells can sometimes trigger an immune response. Additionally, there's a risk that pluripotent stem cells may form benign tumors, which remains a critical safety issue that needs to be addressed before widespread clinical use.
As research continues, the potential of iPS cells to revolutionize regenerative medicine remains a powerful motivation for scientists worldwide.